High Intensity Focused Ultrasound/HIFU
Also known as Ablatherm device, Sonablate 500 device (SB500)
[Alternative]

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Category: Light/heat/sound/energy

Summary:

High Intensity Focused Ultrasound, HIFU, is a non-invasive therapy that uses focused ultrasound to generate precise areas of intense heat to destroy tumours, while leaving surrounding tissue unaffected. This therapy has been studied for around 50 years, with recent developments allowing use on tumours of the liver, kidney, bone, pancreatic, prostate and other areas. It has minimal or no side effects and can be safely repeated if necessary.


See What Other people are saying about High Intensity Focused Ultrasound/HIFU

Description:

High Intensity Focused Ultrasound or HIFU, uses high energy, high frequency, focused sound waves to destroy precise volumes of tissue within a tumour without damaging surrounding structures. This pulse of high energy ultrasound can be focused onto a single location the size of a grain of rice. When directed at a delivery point, the temperature increases, causing the fats (lipids) in the cell membrane to melt and the proteins to denature, destroying a small volume of tissue. With the treatment of prostate cancer, targeting can be planned in order to preserve the vital structures around the glands that are involved in preservation of continence and erectile function.

HIFU treatment can stimulate the immune system which can, on its own, have an effect on tumours that have not been directly targeted.

Small tumours can be destroyed in one session, but often large tumours require more sessions. In some cases there are advantages in combining HIFU with other medical treatments. Sessions are followed up with MRI scans to confirm tumour destruction.

With HIFU, there has been no evidence of side effects. Occasionally the skin is affected with a mild sunburn effect which clears up after a few days. The use of anaesthetic eliminates any discomfort allowing the patient to keep still during treatment.



History:

Ultrasound transducers were first developed by P. Langevin during the 20th century. He used the piezoelectric properties of quartz crystal to construct the first submarine sonar.

In the 1940s, the first investigations of HIFU for non-invasive ablation were reported by Lynn et al. During the 1940s and 1960s, important work was performed by William and Francis Fry at Illinois University. This culminated in clinical treatments of neurological disorders such as Parkinson's disease. Using a set of ultrasound transducers, which were focused on an area to be treated, tiny biological lesions located deep within the cerebral cortex could be reached.

Until recently, there have only been a few clinical trials of HIFU for ablation (although significant work in hyperthermia has been performed using ultrasonic heating). This was perhaps due to the complexity of the treatment and the difficulty of targeting the ultrasonic beam non-invasively. Due to recent advances in ultrasound technology and medical imaging, there has been an increase in interest in HIFU ablation of tumours.



Notes:

Case studies for further reading:

High-intensity focused ultrasound provides palliation for liver metastasis causing gastric outlet obstruction: case report.

Surgery is the standard of care in several oncologic diseases. However, when non-surgical candidates are not suitable for radical treatment, palliation must be achieved at least. High-intensity focused ultrasound uses ultrasound power that can be sharply focused for highly localised application, as it is a completely non-invasive procedure. Its non-invasiveness appears to be of paramount importance in critically ill patients. Click here to read more

HIFU outcomes in Germany after an average of 8 years of follow-up

Researchers at the University of Regensburg in Germany have just reported progression-free survival data from their 14-year experience of using high-intensity focused ultrasound (HIFU) in the treatment of localized prostate cancer. This research group was one of the first to start testing the use of HIFU in the treatment of prostate cancer. Click here to read more




Cancers: Bone, Kidney, Liver, Pancreatic, Prostate



Important Information:

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This therapy, or information about it, is available from:

St Vincents Clinic (clinic)
38 Victoria Street
Darlinghurst
NSW
2010
Australia
http://www.clinic.stvincents.com.au
clinic@stvincents.com.au
Telephone: +61 2838 266222


Royal Free Hospital (The) (clinic)
Urology Department
Pond Street
London
London
NW3 2QG
UK - England (South East)
http://www.royalfree.nhs.uk/urology.aspx?top_nav_id=1&tab_id=1420
Telephone: +44 (0)20 7794 0500
Telephone (alt): +44 (0)844 848 0700


King George Hospital NHS Foundation Trust (The) (clinic)
Barley Lane
Goodmayes
Essex
IG3 8YB
UK - England (South East)
http://www.bhrhospitals.nhs.uk/our-services/urology.htm
Telephone: +44 (0)2089 838000
Telephone (alt): +44 (0)845 130 4204


Royal Surrey County Hospital NHS Foundation Trust (The) (clinic)
Egerton Road
Guildford
Surrey
GU2 7XX
UK - England (South East)
http://www.royalsurrey.nhs.uk/Services/Urology
rsc-tr.enquiries@nhs.net
Telephone: +44 (0)1438 571122


Brighton and Sussex University Hospital (clinic)
Eastern Road
Brighton
East Sussex
BN2 5BE
UK - England (South East)
http://www.bsuh.nhs.uk/departments/cancer-services/
Telephone: +44 (0)1273 696955
Telephone (alt): +44 (0)1273 697808


Wellington Hospital (The) (clinic)
The South Building
Wellington Place, St John's Wood
London
London
NW8 9LE
UK - England (South East)
http://www.thewellingtonhospital.com/our-services/urology/overview
http://www.londonurologyspecialists.com
wellington.enquiryhelpline@hcahealthcare.co.uk
Telephone: +44 (0)20 7483 5148
Telephone (alt): +44 (0)20 7586 5959


Princess Royal Hospital NHS Trust (clinic)
Lewes Road
Haywards Heath
West Sussex
RH16 4EX
UK - England (South East)
http://www.bsuh.nhs.uk/hospitals/our-hospitals/princess-royal-hospital
Telephone: +44 (0)1444 441881


Stepping Hill Hospital NHS Trust (clinic)
Urology Department
Poplar Grove
Stockport
Greater Manchester
SK2 7JE
UK - England (North)
http://www.stockport.nhs.uk/serviceview/24/urology
trust.enquiries@stockport.nhs.uk
Telephone: +44 (0)1614 195698
Telephone (alt): +44 (0)1614 195697


Nuffield Health (clinic)
Nuffield Guildford Hospital
Stirling Road
Guildford
Surrey
GU2 7RF
UK - England (South East)
http://www.nuffieldhealth.com/hospitals/guildford
guildford.enquiries@nuffieldhealth.com
Telephone: +44 (0)1483 555800
Telephone (alt): +44 (0)1483 555888


Nuffield Health (clinic)
Nuffield Brighton Hospital
Warren Road
Brighton
Sussex
BN2 6DX
UK - England (South East)
http://www.nuffieldhealth.com/hospitals/brighton
brighton.enquiries@nuffieldhealth.com
Telephone: +44 (0)1273 627007
Telephone (alt): +44 (0)845 619 1175


Nuffield Health (clinic)
Nuffield Brentwood Hospital
Shenfield Road
Brentwood
Essex
CM15 8EH
UK - England (South East)
http://www.nuffieldhealth.com/hospitals/brentwood
brentwood.enquiries@nuffieldhealth.com
Telephone: +44 (0)1277 889035
Telephone (alt): +44 (0)845 619 1175


BMI Healthcare (clinic)
BMI Goring Hall Hospital
Bodiam Avenue
Goring-by-Sea
West Sussex
BN12 5AT
UK - England (South East)
http://www.bmihealthcare.co.uk
Telephone: +44 (0)1903 506699
Telephone (alt): +44 (0)800 051 5045


BMI Healthcare (clinic)
BMI The Winterbourne Hospital
Herringston Road
Dorchester
Dorset
DT1 2DR
UK - England (South West)
http://www.bmihealthcare.co.uk
Telephone: +44 (0)1305 263252
Telephone (alt): +44 (0)808 101 0337


BMI Healthcare (clinic)
BMI Bishops Wood Hospital
Rickmansworth Road
Northwood
Middlesex
HA6 2JW
UK - England (South East)
http://www.bmihealthcare.co.uk
Telephone: +44 (0)1923 835814


BMI Healthcare (clinic)
BMI The Chaucer Hospital
Nackington Road
Canterbury
Kent
CT4 7AR
UK - England (South East)
http://www.bmihealthcare.co.uk
Telephone: +44 (0)1227 825100
Telephone (alt): +44 (0)808 101 0337


BMI Healthcare (clinic)
BMI Coombe Wing
Level 7, Esher Wing, Kingston Hospital NHS Trust
Kingston upon Thames
Surrey
KT2 7QB
UK - England (South East)
http://www.bmihealthcare.co.uk
Telephone: +44 (0)2085 466677
Telephone (alt): +44 (0)808 101 0337


BMI Healthcare (clinic)
BMI The Edgbaston Hospital
22 Somerset Road, Edgbaston
Birmingham
West Midlands
B15 2QQ
UK - England (Midlands)
http://www.bmihealthcare.co.uk
Telephone: +44 (0)12 1456 2000
Telephone (alt): +44 (0)808 101 0337


BMI Healthcare (clinic)
BMI The Foscote Hospital
2 Foscote Rise
Banbury
Oxfordshire
OX16 9XP
UK - England (South East)
http://www.bmihealthcare.co.uk
Telephone: +44 (0)1295 252281
Telephone (alt): +44 (0)808 101 0337


BMI Healthcare (clinic)
BMI The Hampshire Clinic
Basing Road, Old Basing
Basingstoke
Hampshire
RG24 7AL
UK - England (South East)
http://www.bmihealthcare.co.uk
Telephone: +44 (0)1256 357111
Telephone (alt): +44 (0)808 101 0337


BMI Healthcare (clinic)
BMI Mount Alvernia Hospital
Harvey Road
Guildford
Surrey
GU1 3LX
UK - England (South East)
http://www.bmihealthcare.co.uk
Telephone: +44 (0)1483 570122
Telephone (alt): +44 (0)808 101 0337


BMI Healthcare (clinic)
BMI The Park Hospital
Sherwood Lodge Drive, Burntstump Country Park
Nottingham
Nottinghamshire
NG5 8RX
UK - England (Midlands)
http://www.bmihealthcare.co.uk
Telephone: +44 (0)1159 662000
Telephone (alt): +44 (0)808 101 0337


BMI Healthcare (clinic)
BMI The Princess Margaret Hospital
Osborne Road
Windsor
Berkshire
SL4 3SJ
UK - England (South East)
http://www.bmihealthcare.co.uk
Telephone: +44 (0)1753 743434
Telephone (alt): +44 (0)808 101 0337


BMI Healthcare (clinic)
BMI The Priory Hospital
Priory Road, Edgbaston
Birmingham
West Midlands
B5 7UG
UK - England (Midlands)
http://www.bmihealthcare.co.uk
Telephone: +44 (0)12 1440 2323


BMI Healthcare (clinic)
BMI Ross Hall Hospital
221 Crookston Road
Glasgow
Glasgow
G52 3NQ
UK - Scotland
http://www.bmihealthcare.co.uk
Telephone: +44 (0)14 1810 3151


BMI Healthcare (clinic)
BMI The Saxon Clinic
Chadwick Drive, Saxon Street
Milton Keynes
Buckinghamshire
MK6 5LR
UK - England (South East)
http://www.bmihealthcare.co.uk
Telephone: +44 (0)1908 665533
Telephone (alt): +44 (0)808 101 0337


BMI Healthcare (clinic)
BMI Syon Clinic
941 Great West Road
Brentford
Middlesex
TW8 9DU
UK - England (South East)
http://www.bmihealthcare.co.uk
Telephone: +44 (0)2083 226000


Nuada Medical Prostate Care (clinic)
45 Queen Anne Street
London
London
W1G 9JF
UK - England (South East)
http://www.nuadamedical.co.uk
prostates@nuadamedical.com
Telephone: +44 (0)20 7036 8850
Telephone (alt): +44 (0)20 7036 8800


Dr Stefan Thüroff
HIFU Clinic (The) (clinic)
Szczerkowskiego 4 05-827
Grodzisk Mazowiecki
Poland
http://www.hifu.pl/en/
contact@hifu.pl
Telephone: +p48 22 734 40 34


Essex Urology at Springfield Hospital (clinic)
Lawn Lane
Springfield
Chelmsford
Essex
CM1 7GU
UK - England (South East)
http://www.essexurology.co.uk
http://www.springfieldhospital.co.uk/treatments/cancer-services
Telephone: +44 (0)845 130 1590
Telephone (alt): +44 (0)1245 234158