Photodynamic Therapy (PDT)
Also known as PDT, Cytoluminescent Therapy, CLT, Phototherapy
[Alternative]

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Category: Light/heat/sound/energy

Summary:

A photosensitising (light activated) drug is first administered to patients followed by irradiation of cancerous tissue with laser light, which converts the drug into a powerful cytotoxic (cell destroying) agent. This therapy is applicable to a wide range of solid tumours, the limiting factor often being access to the tumour to perform the procedure.


See What Other people are saying about Photodynamic Therapy (PDT)

Description:

Photodynamic Therapy takes advantage of a chemical interaction between light and a light-activated drug (photosensitiser) to start a series of chemical reactions that kill tumours. With modern photosensitisers, certain physiological properties of tumour tissue can be exploited to retain high concentrations of the drug in cancerous tissues only.

Cytoluminescent Therapy (CLT) is a recent development in the field of Photodynamic Therapy that uses a specific extract of chlorophyll A, trade name Photoflora as its photosensitiser. Photoflora can be given to a patient orally and accumulates selectively in tumour sites and is cleared from the skin between 24-48 hours so that sun sensitivity is not a problem as it can be in some other photosensitisers.

Previous photosensitisers required the use of lasers, but Photoflora is a whole body therapy with the use of a specialised light bed to sensitise the agent. The agent used is sensitive to ultrasound as well as to red light, therefore allowing deeper penetration. The therapy can be often repeated as Photfloras abiity to keep photosensitive can last up to 90 days. Advanced tumours are treated slowly to avoid rapid breakdown. This method shows promise but would still be described by medical authorities as experimental and unproven. Due to lack of penetration, its effectiveness is limited to lesions on or close to the surface of the body.

PDT has now an established evidence base whilst CLT is largely untrialled.



History:

Therapeutic properties of light have been known and used for thousands of years. Indian, ancient Egyptian and Chinese civilizations have used light to treat various diseases such as psoriasis, rickets and types of skin cancer.

In Denmark at the end of the nineteenth century, Niels Finsen developed the use of red light to treat smallpox and ultraviolet light to treat tuberculosis. This was the start of modern Light Therapy. Finsen was awarded a Nobel Prize in 1903 for his work. Two German medical students, Oscar Raab and Herman Von Tappeiner went on to further develop this therapy using certain wavelengths.



Notes:

Photodynamic Therapy is available on the NHS but will not often be offered as an option. If you are interested in considering PDT then you may need to ask for a referral. The charity Killing Cancer (see listing below) can be very helpful in obtaining a referral, if appropriate.




Cancers: Bowel, Breast, Colon/rectal, Liver, Melanoma, Mouth, Oesophagael, Pancreatic, Prostate, Small cell lung, Stomach, Throat



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This therapy, or information about it, is available from:

BioMed Klinik (clinic)
Tischberger Str. 5-8
Bad Bergzabern
D-76887
Germany
http://www.biomed-klinik.de
medinfo@biomed-klinik.de
request@biomedhospital.com
Telephone: +49 6343 705-0
Telephone (alt): +49 6343 705 357


Mr Ernest Allen
Christie NHS Foundation Trust (The) (clinic)
Wilmslow Road
Manchester
Greater Manchester
M20 4BX
UK - England (North)
Telephone: +44 (0)16 1446 3000


ITL Cancer Clinic (clinic)
East Atlantic Drive
Freeport
Grand Bahama
Bahamas
http://www.immunemedicine.com
mail@immunmedicine.com
Telephone: +242 352 7455


Killing Cancer (information/advice)
Lodge Farm Cottage
Grafham Road
Huntingdon
Cambridgeshire
PE28 0DB
UK - England (South East)
http://www.killingcancer.co.uk
info@killingcancer.co.uk


Klinik St. George (clinic)
St.George Hospital Gmbh
Rosenheimer Strasse 6-8
Bad Aibling
D-83043
Germany
http://www.klinik-st-georg.de
info@klinik-st-georg.de
Telephone: +49 8061 3980


Dr Stephen Bown
Mr Colin Hopper
National Medical Laser Centre (clinic)
7-73 Riding House St
London
London
W1W 7EJ
UK - England (South East)
http://www.ucl.ac.uk/surgicalscience/departments_research/gsrg/nmlc
med.laser@ucl.ac.uk
Telephone: +44 (0)20 7679 9060


PDT Norfolk (clinic)
PO Box 3550
Norwich
Norfolk
NR7 7TY
UK - England (South East)
http://www.pdtnorfolk.co.uk
info@pdtnorfolk.co.uk
Telephone: +44 (0)1263 824868


Roswell Park Cancer Institute (clinic)
Elm & Carleton Streets
Buffalo
New York
NY 14263
United States
http://www.roswellpark.org
askrpci@roswellpark.org
Telephone: +1 877 275 7724


Royal Devon and Exeter NHS Foundation Trust (clinic)
Barrack Road
Exeter
Devon
EX2 5DW
UK - England (South West)
http://www.rdehospital.nhs.uk
rde-tr.WebComments@nhs.net
Telephone: +44 (0)1392 411611


Scottish Photodynamic Therapy Centre (The) (clinic)
Ninewells Hospital
Dundee
Angus
DD1 9SY
UK - Scotland
http://www.medi-lase.co.uk/the-scottish-photodynamic-therapy-centre
cgoodman@nhs.net
Telephone: +44 (0)13 8249 6498


University Hospital of South Manchester (clinic)
North West Lung Centre, Wythenshawe Hospital
Southmoor Road
Wythenshawe
Manchester
M23 9LT
UK - England (North)
http://www.uhsm.nhs.uk/nwlungcentre/Pages/home.aspx
Telephone: +44 (0)1612 912840


Prof Keyvan Moghissi
Yorkshire Laser Centre (clinic)
The UK Medical Laser Centre
Goole and District Hospital, Woodlands Avenue
Goole
East Riding of Yorkshire
DN14 6RX
UK - England (North)
http://www.yorkshirelasercentre.org
kdixon@yorkshirelasercentre.org
Telephone: +44 (0)1724 290456