High Intensity Focused Ultrasound, HIFU, is a non-invasive therapy that uses focused ultrasound to generate precise areas of intense heat to destroy tumours, while leaving surrounding tissue unaffected. This therapy has been studied for around 50 years, with recent developments allowing use on tumours of the liver, kidney, bone, pancreatic, prostate and other areas. It has minimal or no side effects and can be safely repeated if necessary.

Ultrasound transducers were first developed by P. Langevin during the 20th century. He used the piezoelectric properties of quartz crystal to construct the first submarine sonar.In the 1940s, the first investigations of HIFU for non-invasive ablation were reported by Lynn et al. During the 1940s and 1960s, important work was performed by William and Francis Fry at Illinois University. This culminated in clinical treatments of neurological disorders such as Parkinson’s disease. Using a set of ultrasound transducers, which were focused on an area to be treated, tiny biological lesions located deep within the cerebral cortex could be reached.

Until recently, there have only been a few clinical trials of HIFU for ablation (although significant work in hyperthermia has been performed using ultrasonic heating). This was perhaps due to the complexity of the treatment and the difficulty of targeting the ultrasonic beam non-invasively. Due to recent advances in ultrasound technology and medical imaging, there has been an increase in interest in HIFU ablation of tumours.

Case studies for further reading: http://www.jtultrasound.com/content/1/1/9. High-intensity focused ultrasound provides palliation for liver metastasis causing gastric outlet obstruction: case report. Surgery is the standard of care in several oncologic diseases. However, when non-surgical candidates are not suitable for radical treatment, palliation must be achieved at least. High-intensity focused ultrasound uses ultrasound power that can be sharply focused for highly localised application, as it is a completely non-invasive procedure. Its non-invasiveness appears to be of paramount importance in critically ill patients. http://www.jtultrasound.com/content/1/1/9. Click here to read more http://prostatecancerinfolink.net/2013/03/04/hifu-outcomes-in-germany-after-an-average-of-8-years-of-follow-up/. HIFU outcomes in Germany after an average of 8 years of follow-up. Researchers at the University of Regensburg in Germany have just reported progression-free survival data from their 14-year experience of using high-intensity focused ultrasound (HIFU) in the treatment of localised prostate cancer. This research group was one of the first to start testing the use of HIFU in the treatment of prostate cancer. http://prostatecancerinfolink.net/2013/03/04/hifu-outcomes-in-germany-after-an-average-of-8-years-of-follow-up/ Click here to read more